IMMUNOHISTOCHEMICAL STUDY OF c-erbB-2 PROTO-ONCOGENE PRODUCT IN PROSTATIC CANCER
نویسندگان
چکیده
منابع مشابه
Altered expression of RET proto-oncogene product in prostatic intraepithelial neoplasia and prostate cancer.
BACKGROUND The RET proto-oncogene encodes a protein that belongs to the tyrosine kinase growth factor receptor family. Germline point mutations in RET are found in individuals with multiple endocrine neoplasia (MEN) syndromes, and gene rearrangements have been reported in papillary thyroid cancers. We recently identified transcripts of the RET proto-oncogene in human prostate cancer xenografts ...
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The search for the precursor of invasive prostatic adenocarcinoma has intensified in recent years, focusing on the spectrum of histopathologic changes referred to as high-grade prostatic intraepithelial neoplasia. This microscopic finding, considered to be the most likely precursor of invasive carcinoma (7), is characterized by cellular proliferations within pre-existing ducts and glands, with ...
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AIMS To establish the prevalence of c-erbB-2 protein expression in a surgical series of Barrett's adenocarcinomas; and to correlate this expression with clinicopathological data and prognosis. METHODS Sixty six surgical specimens of Barrett's adenocarcinomas were included in this retrospective study. Blocks of the tumour and of non-dysplastic Barrett's mucosa were stained with a polyclonal an...
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ژورنال
عنوان ژورنال: The Japanese Journal of Urology
سال: 1993
ISSN: 0021-5287,1884-7110
DOI: 10.5980/jpnjurol1989.84.1872